Preclinical mouse models of osteosarcoma
نویسندگان
چکیده
منابع مشابه
Preclinical mouse models of osteosarcoma.
Osteosarcoma is the most common form of primary bone tumors with high prevalence in children. Survival rates of osteosarcoma are low, especially in the case of metastases. Mouse models of this disease have been very valuable in investigation of mechanisms of tumorigenesis, metastasis, as well as testing possible therapeutic options. In this chapter, we summarize currently available mouse models...
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Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for non-metastatic disease approaching 70%. However, most OS tumors are high grade and tend to rapidly develop pulmonary metastases. Despite clinical advances, patients with metastatic disease ...
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ژورنال
عنوان ژورنال: BoneKEy Reports
سال: 2015
ISSN: 2047-6396
DOI: 10.1038/bonekey.2015.37